Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues
نویسندگان
چکیده
منابع مشابه
In vitro production of mouse mammary tumor virus in a mouse mammary tumor ascites line.
An ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro, large amounts of oncornavirus particles. The biochemical, biophysical, and electron microscopic characteristics of the virions are described. Molecular hybridization and immunological methods identify these virions as mouse mammary tumor virus.
متن کاملCharacterization, chromosome assignment, and segregation analysis of endogenous proviral units of mouse mammary tumor virus.
In the course of analyzing sites of proviral integration in tumors induced by mouse mammary tumor virus (MMTV), we have isolated recombinant DNA clones corresponding to the 5' and 3' ends of four endogenous MMTV proviruses present in BALB/c and BR6 mice. This has permitted the structural characterization of each locus by detailed restriction mapping and the preparation of DNA probes specific fo...
متن کاملCryoelectron microscopy of mouse mammary tumor virus.
Cryoelectron microscopy of Mouse mammary tumor virus, a Betaretrovirus, provided information about glycoprotein structure and core formation. The virions showed the broad range of diameters typical of retroviruses. Betaretroviruses assemble cytoplasmically, so the broad size range cannot reflect the use of the plasma membrane as a platform for assembly.
متن کاملGenes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors
The accumulation of mutations is a contributing factor in the initiation of premalignant mammary lesions and their progression to malignancy and metastasis. We have used a mouse model in which the carcinogen is the mouse mammary tumor virus (MMTV) which induces clonal premalignant mammary lesions and malignant mammary tumors by insertional mutagenesis. Identification of the genes and signaling ...
متن کاملEstrogen receptor in normal and neoplastic mouse mammary tissues.
apparent correlation between the susceptibility of a strain to mammary tumor development and the ability of its normal mammary gland receptors to bind estradici. The receptor appears to be in the parenchyma! elements of the gland. The spontaneous mammary tumor showed binding capacities significantly lower than the normal gland, based on wet weight tissue and DNA content. There is no correlation...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1984
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.49.1.66-71.1984